SIRT1 and SIRT2 Modulators: Potential Anti-Inflammatory Treatment for Depression?

ABSTRACT: Depression is a psychiatric disorder that has a significant health burden on patients and their families. Unfortunately, the current antidepressant medications that mainly target monoamine neurotransmitters have limited efficacy. Recent evidence has indicated that neuroinflammation participates in the genesis and development of depression, and interacts with other factors involved in depression. Therefore, exploring effective anti-inflammatory medications could be beneficial for the development of new treatment options for depression. Sirtuins are a unique class of nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases, which have seven members that can affect multiple downstream targets by deacetylation activity. Among these seven members, SIRT1 and SIRT2 have been shown to parti

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC7996578 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature