Differential Leukocyte and Platelet Profiles in Distinct Models of Traumatic Brain Injury.

ABSTRACT: Traumatic brain injury (TBI) affects over 3 million individuals every year in the U.S. There is growing appreciation that TBI can produce systemic modifications, which are in part propagated through blood-brain barrier (BBB) dysfunction and blood-brain cell interactions. As such, platelets and leukocytes contribute to mechanisms of thromboinflammation after TBI. While these mechanisms have been investigated in experimental models of contusion brain injury, less is known regarding acute alterations following mild closed head injury. To investigate the role of platelet dynamics and bioenergetics after TBI, we employed two distinct, well-established models of TBI in mice: the controlled cortical impact (CCI) model of contusion brain injury and the closed head injury (CHI) model of mild diffus

SUBMITTER: Hubbard WB 

PROVIDER: S-EPMC7996744 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature