Sleep-Wake Cycle and EEG-Based Biomarkers during Late Neonate to Adult Transition.

ABSTRACT: During the transition from neonate to adulthood, brain maturation establishes coherence between behavioral states-wakefulness, non-rapid eye movement, and rapid eye movement sleep. In animal models few studies have characterized and analyzed cerebral rhythms and the sleep-wake cycle in early ages, in relation to adulthood. Since the analysis of sleep in early ages can be used as a predictive model of brain development and the subsequent emergence of neural disturbances in adults, we performed a study on late neonatal mice, an age not previously characterized. We acquired longitudinal 24 h electroencephalogram and electromyogram recordings and performed time and spectral analyses. We compared both age groups and found that late neonates: (i) spent more time in wakefulness and less time in n

SUBMITTER: Herrero MA 

PROVIDER: S-EPMC7996792 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature