Regional Gray Matter Volume Changes in Parkinson's Disease with Orthostatic Hypotension.

ABSTRACT: Neurodegenerative change in the central nervous system has been suggested as one of the pathophysiological mechanisms of autonomic nervous system dysfunction in Parkinson's disease (PD). We analyzed gray matter (GM) volume changes and clinical parameters in patients with PD to investigate any involvement in the brain structures responsible for autonomic control in patients with PD having orthostatic hypotension (OH). Voxel-based morphometry was applied to compare regional GM volumes between PD patients with and without OH. Multivariate logistic regression analysis using a hierarchical model was carried out to identify clinical factors independently contributing to the regional GM volume changes in PD patients with OH. The Sobel test was used to analyze mediation effects between the indepen

SUBMITTER: Kim JB 

PROVIDER: S-EPMC7996881 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature