¹⁸F-fluorodeoxyglucose positron emission tomography correlates with tumor immunometabolic phenotypes in resected lung cancer.

ABSTRACT: Enhanced tumor glycolytic activity is a mechanism by which tumors induce an immunosuppressive environment to resist adoptive T cell therapy; therefore, methods of assessing intratumoral glycolytic activity are of considerable clinical interest. In this study, we characterized the relationships among tumor ¹⁸F-fluorodeoxyglucose (FDG) retention, tumor metabolic and immune phenotypes, and survival in patients with resected non-small cell lung cancer (NSCLC). We retrospectively analyzed tumor preoperative positron emission tomography (PET) ¹⁸F-FDG uptake in 59 resected NSCLCs and investigated correlations between PET parameters (SUV_Max, SUV_Total, SUV_Mean, TLG), tumor expression of glycolysis- and immune-related genes, and tumor-associated

SUBMITTER: Mitchell KG 

PROVIDER: S-EPMC7997043 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature