A unified framework for inferring the multi-scale organization of chromatin domains from Hi-C.

ABSTRACT: Chromosomes are giant chain molecules organized into an ensemble of three-dimensional structures characterized with its genomic state and the corresponding biological functions. Despite the strong cell-to-cell heterogeneity, the cell-type specific pattern demonstrated in high-throughput chromosome conformation capture (Hi-C) data hints at a valuable link between structure and function, which makes inference of chromatin domains (CDs) from the pattern of Hi-C a central problem in genome research. Here we present a unified method for analyzing Hi-C data to determine spatial organization of CDs over multiple genomic scales. By applying statistical physics-based clustering analysis to a polymer physics model of the chromosome, our method identifies the CDs that best represent the global patter

SUBMITTER: Bak JH 

PROVIDER: S-EPMC7997044 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature