Transcriptional programmes underlying cellular identity and microbial responsiveness in the intestinal epithelium.

ABSTRACT: The intestinal epithelium serves the unique and critical function of harvesting dietary nutrients, while simultaneously acting as a cellular barrier separating tissues from the luminal environment and gut microbial ecosystem. Two salient features of the intestinal epithelium enable it to perform these complex functions. First, cells within the intestinal epithelium achieve a wide range of specialized identities, including different cell types and distinct anterior-posterior patterning along the intestine. Second, intestinal epithelial cells are sensitive and responsive to the dynamic milieu of dietary nutrients, xenobiotics and microorganisms encountered in the intestinal luminal environment. These diverse identities and responsiveness of intestinal epithelial cells are achieved in part th

SUBMITTER: Heppert JK 

PROVIDER: S-EPMC7997278 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature