Effect of Selenium and Iodine on Oxidative Stress in the First Trimester Human Placenta Explants.

ABSTRACT: Imbalanced maternal micronutrient status, poor placentation, and oxidative stress are associated with greater risk of pregnancy complications, which impact mother and offspring health. As selenium, iodine, and copper are essential micronutrients with key roles in antioxidant systems, this study investigated their potential protective effects on placenta against oxidative stress. First trimester human placenta explants were treated with different concentrations of selenium (sodium selenite), iodine (potassium iodide), their combination or copper (copper (II) sulfate). The concentrations represented deficient, physiological, or super physiological levels. Oxidative stress was induced by menadione or antimycin. Placenta explants were collected, fixed, processed, and embedded for laser ablatio

SUBMITTER: Habibi N 

PROVIDER: S-EPMC7997475 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature