Insights into Cisplatin Binding to Uracil and Thiouracils from IRMPD Spectroscopy and Tandem Mass Spectrometry.

ABSTRACT: The monofunctional primary complexes cis-[PtCl(NH₃)₂(L)]⁺, formed by the reaction of cisplatin, a major chemotherapeutic agent, with four nucleobases L, i.e., uracil (U), 2-thiouracil (2SU), 4-thiouracil (4SU), and 2,4-dithiouracil (24dSU), have been studied by a combination of infrared multiple photon dissociation (IRMPD) action spectroscopy in both the fingerprint (900-1900 cm^-1) and the N-H/O-H stretching (3000-3800 cm^-1) ranges, energy-resolved collision-induced dissociation (CID) mass spectrometry, and density functional calculations at the B3LYP/LACVP/6-311G** level. On the basis of the comparison across the experimental features and the linear IR spectra of conceivable structures, the cisplatin residue is found to promote

SUBMITTER: Corinti D 

PROVIDER: S-EPMC7997577 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature