Ontology highlight
ABSTRACT:
SUBMITTER: Alghanem AF
PROVIDER: S-EPMC7997661 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Alghanem Ahmad F AF Abello Javier J Maurer Joshua M JM Kumar Ashutosh A Ta Chau My CM Gunasekar Susheel K SK Fatima Urooj U Kang Chen C Xie Litao L Adeola Oluwaseun O Riker Megan M Elliot-Hudson Macaulay M Minerath Rachel A RA Grueter Chad E CE Mullins Robert F RF Stratman Amber N AN Sah Rajan R
eLife 20210225
The endothelium responds to numerous chemical and mechanical factors in regulating vascular tone, blood pressure, and blood flow. The endothelial volume-regulated anion channel (VRAC) has been proposed to be mechanosensitive and thereby sense fluid flow and hydrostatic pressure to regulate vascular function. Here, we show that the leucine-rich repeat-containing protein 8a, LRRC8A (SWELL1), is required for VRAC in human umbilical vein endothelial cells (HUVECs). Endothelial LRRC8A regulates AKT-e ...[more]