High-fiber diets attenuate emphysema development via modulation of gut microbiota and metabolism.

ABSTRACT: Dietary fiber functions as a prebiotic to determine the gut microbe composition. The gut microbiota influences the metabolic functions and immune responses in human health. The gut microbiota and metabolites produced by various dietary components not only modulate immunity but also impact various organs. Although recent findings have suggested that microbial dysbiosis is associated with several respiratory diseases, including asthma, cystic fibrosis, and allergy, the role of microbiota and metabolites produced by dietary nutrients with respect to pulmonary disease remains unclear. Therefore, we explored whether the gut microbiota and metabolites produced by dietary fiber components could influence a cigarette smoking (CS)-exposed emphysema model. In this study, it was demonstrated that a h

SUBMITTER: Jang YO 

PROVIDER: S-EPMC7997879 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature