Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC7997881 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Li Yijian Y Ge Lingling L Chen Xia X Mao Yumei Y Gu Xianliang X Ren Bangqi B Zeng Yuxiao Y Chen Min M Chen Siyu S Liu Jinhua J Yang Yuli Y Xu Haiwei H
NPJ Regenerative medicine 20210326 1
Regeneration/repair after injury can be endowed by adult stem cells (ASCs) or lineage restricted and even terminally differentiated cells. In corneal epithelium, regeneration after a large wound depends on ASCs (limbal epithelial stem cells, LESCs), whereas repair after a small wound is LESCs-independent. Here, using rat corneal epithelial wounds with different sizes, we show that YAP activation promotes the activation and expansion of LESCs after a large wound, as well as the reprogramming of l ...[more]