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The common YAP activation mediates corneal epithelial regeneration and repair with different-sized wounds.


ABSTRACT: Regeneration/repair after injury can be endowed by adult stem cells (ASCs) or lineage restricted and even terminally differentiated cells. In corneal epithelium, regeneration after a large wound depends on ASCs (limbal epithelial stem cells, LESCs), whereas repair after a small wound is LESCs-independent. Here, using rat corneal epithelial wounds with different sizes, we show that YAP activation promotes the activation and expansion of LESCs after a large wound, as well as the reprogramming of local epithelial cells (repairing epithelial cells) after a small wound, which contributes to LESCs-dependent and -independent wound healing, respectively. Mechanically, we highlight that the reciprocal regulation of YAP activity and the assembly of cell junction and cortical F-actin cytoskeleton accelerates corneal epithelial healing with different-sized wounds. Together, the common YAP activation and the underlying regulatory mechanism are harnessed by LESCs and lineage-restricted epithelial cells to cope with corneal epithelial wounds with different sizes.

SUBMITTER: Li Y 

PROVIDER: S-EPMC7997881 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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The common YAP activation mediates corneal epithelial regeneration and repair with different-sized wounds.

Li Yijian Y   Ge Lingling L   Chen Xia X   Mao Yumei Y   Gu Xianliang X   Ren Bangqi B   Zeng Yuxiao Y   Chen Min M   Chen Siyu S   Liu Jinhua J   Yang Yuli Y   Xu Haiwei H  

NPJ Regenerative medicine 20210326 1


Regeneration/repair after injury can be endowed by adult stem cells (ASCs) or lineage restricted and even terminally differentiated cells. In corneal epithelium, regeneration after a large wound depends on ASCs (limbal epithelial stem cells, LESCs), whereas repair after a small wound is LESCs-independent. Here, using rat corneal epithelial wounds with different sizes, we show that YAP activation promotes the activation and expansion of LESCs after a large wound, as well as the reprogramming of l  ...[more]

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