Phosphoprotein enriched in astrocytes (PEA)-15 is a novel regulator of adipose tissue expansion.

ABSTRACT: Excessive expansion of adipose tissue in obesity typically leads to overflow and accumulation of lipids in other tissues, causing fatty liver disease and atherosclerosis. The intracellular protein, phosphoprotein enriched in astrocytes (PEA)-15 has been linked to metabolic disease but its role in lipid storage has not been examined. To delineate the role of PEA-15 in adipose tissue, we placed PEA-15^-/- mice on a high fat diet. These mice developed increased body weight and greater white adipose tissue expansion compared to high fat diet-fed wild type mice. This was due to increased adipocyte cell size in PEA-15^-/- mice consistent with greater lipid storage capacity. Surprisingly, PEA-15^-/- mice exhibited improvements in whole body insulin sensitivity, lower

SUBMITTER: Verschoor PJ 

PROVIDER: S-EPMC7997924 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature