Unc13A and Unc13B contribute to the decoding of distinct sensory information in Drosophila.

ABSTRACT: The physical distance between presynaptic Ca²⁺ channels and the Ca²⁺ sensors triggering the release of neurotransmitter-containing vesicles regulates short-term plasticity (STP). While STP is highly diversified across synapse types, the computational and behavioral relevance of this diversity remains unclear. In the Drosophila brain, at nanoscale level, we can distinguish distinct coupling distances between Ca²⁺ channels and the (m)unc13 family priming factors, Unc13A and Unc13B. Importantly, coupling distance defines release components with distinct STP characteristics. Here, we show that while Unc13A and Unc13B both contribute to synaptic signalling, they play distinct roles in neural decoding of olfactory information at excitatory projection neuron (ePN)

SUBMITTER: Pooryasin A 

PROVIDER: S-EPMC7997984 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature