Intestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive disease.
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ABSTRACT:
SUBMITTER: Law AE
PROVIDER: S-EPMC7997997 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Publications
Intestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive disease.
Law Alice E AE Shears Rebecca K RK Lopez Rodas Andrea A AA Grencis Richard K RK Cooper Philip J PJ Neill Daniel R DR Kadioglu Aras A
Scientific reports 20210326 1
Infection with Streptococcus pneumoniae is the leading cause of death in children and burden of disease is greatest where helminth infections are also common. We investigated the impact of intestinal helminth co-infection on pneumococcal carriage; a risk factor for invasive disease. We used a mouse co-infection model and clinical data to assess the impact of co-infection on carriage density. Co-infection in mice was associated with increased pneumococcal carriage density and dissemination into l ...[more]
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