Morpho-Functional Consequences of Swiss Cheese Knockdown in Glia of Drosophila melanogaster.

ABSTRACT: Glia are crucial for the normal development and functioning of the nervous system in many animals. Insects are widely used for studies of glia genetics and physiology. Drosophila melanogaster surface glia (perineurial and subperineurial) form a blood-brain barrier in the central nervous system and blood-nerve barrier in the peripheral nervous system. Under the subperineurial glia layer, in the cortical region of the central nervous system, cortex glia encapsulate neuronal cell bodies, whilst in the peripheral nervous system, wrapping glia ensheath axons of peripheral nerves. Here, we show that the expression of the evolutionarily conserved swiss cheese gene is important in several types of glia. swiss cheese knockdown in subperineurial glia leads to morphological abnormalities of these cel

SUBMITTER: Ryabova EV 

PROVIDER: S-EPMC7998100 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature