Characterization of Nanoparticle Adsorption on Polydimethylsiloxane-Based Microchannels.

ABSTRACT: Nanoparticles (NPs) are used in various medicinal applications. Exosomes, bio-derived NPs, are promising biomarkers obtained through separation and concentration from body fluids. Polydimethylsiloxane (PDMS)-based microchannels are well-suited for precise handling of NPs, offering benefits such as high gas permeability and low cytotoxicity. However, the large specific surface area of NPs may result in nonspecific adsorption on the device substrate and thus cause sample loss. Therefore, an understanding of NP adsorption on microchannels is important for the operation of microfluidic devices used for NP handling. Herein, we characterized NP adsorption on PDMS-based substrates and microchannels by atomic force microscopy to correlate NP adsorptivity with the electrostatic interactions associa

SUBMITTER: Hirama H 

PROVIDER: S-EPMC7998103 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature