Mitochondrial Consequences of Organ Preservation Techniques during Liver Transplantation.

ABSTRACT: Allograft ischemia during liver transplantation (LT) adversely affects the function of mitochondria, resulting in impairment of oxidative phosphorylation and compromised post-transplant recovery of the affected organ. Several preservation methods have been developed to improve donor organ quality; however, their effects on mitochondrial functions have not yet been compared. This study aimed to summarize the available data on mitochondrial effects of graft preservation methods in preclinical models of LT. Furthermore, a network meta-analysis was conducted to determine if any of these treatments provide a superior benefit, suggesting that they might be used on humans. A systematic search was conducted using electronic databases (EMBASE, MEDLINE (via PubMed), the Cochrane Central Register of

SUBMITTER: Horvath T 

PROVIDER: S-EPMC7998211 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature