Identification of New Potential Biotherapeutics from Human Gut Microbiota-Derived Bacteria.

ABSTRACT: The role of the gut microbiota in health and disease is well recognized and the microbiota dysbiosis observed in many chronic diseases became a new therapeutic target. The challenge is to get a better insight into the functionality of commensal bacteria and to use this knowledge to select live biotherapeutics as new preventive or therapeutic products. In this study, we set up a screening approach to evaluate the functional capacities of a set of 21 strains isolated from the gut microbiota of neonates and adults. For this purpose, we selected key biological processes involved in the microbiome-host symbiosis and known to impact the host physiology i.e., the production of short-chain fatty acids and the ability to strengthen an epithelial barrier (Caco-2), to induce the release of the anti-i

SUBMITTER: Cuffaro B 

PROVIDER: S-EPMC7998412 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature