Asymmetrical Forces Dictate the Distribution and Morphology of Platelets in Blood Clots.

ABSTRACT: Primary hemostasis consists in the activation of platelets, which spread on the exposed extracellular matrix at the injured vessel surface. Secondary hemostasis, the coagulation cascade, generates a fibrin clot in which activated platelets and other blood cells get trapped. Active platelet-dependent clot retraction reduces the clot volume by extruding the serum. Thus, the clot architecture changes with time of contraction, which may have an important impact on the healing process and the dissolution of the clot, but the precise physiological role of clot retraction is still not completely understood. Since platelets are the only actors to develop force for the retraction of the clot, their distribution within the clot should influence the final clot architecture. We analyzed platelet distr

SUBMITTER: Kovalenko TA 

PROVIDER: S-EPMC7998474 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature