Fighting Oxidative Stress with Sulfur: Hydrogen Sulfide in the Renal and Cardiovascular Systems.

ABSTRACT: Hydrogen sulfide (H₂S) is an essential gaseous signaling molecule. Research on its role in physiological and pathophysiological processes has greatly expanded. Endogenous enzymatic production through the transsulfuration and cysteine catabolism pathways can occur in the kidneys and blood vessels. Furthermore, non-enzymatic pathways are present throughout the body. In the renal and cardiovascular system, H₂S plays an important role in maintaining the redox status at safe levels by promoting scavenging of reactive oxygen species (ROS). H₂S also modifies cysteine residues on key signaling molecules such as keap1/Nrf2, NFκB, and HIF-1α, thereby promoting anti-oxidant mechanisms. Depletion of H₂S is implicated in many age-related and cardiorenal disea

SUBMITTER: Scammahorn JJ 

PROVIDER: S-EPMC7998720 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature