CYP7A1, NPC1L1, ABCB1, and CD36 Polymorphisms Are Associated with Increased Serum Coenzyme Q₁₀ after Long-Term Supplementation in Women.

ABSTRACT: Coenzyme Q₁₀ (CoQ₁₀), an essential component for energy production that exhibits antioxidant activity, is considered a health-supporting and antiaging supplement. However, intervention-controlled studies have provided variable results on CoQ₁₀ supplementation benefits, which may be attributed to individual CoQ₁₀ bioavailability differences. This study aimed to investigate the relationship between genetic polymorphisms and CoQ₁₀ serum levels after long-term supplementation. CoQ₁₀ levels at baseline and after one year of supplementation (150 mg) were determined, and eight single nucleotide polymorphisms (SNPs) in cholesterol metabolism and CoQ₁₀ absorption, efflux, and cellular uptake related genes were assessed. Rs

SUBMITTER: Takahashi M 

PROVIDER: S-EPMC7998724 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature