LncRNAs and microRNAs as Essential Regulators of Stemness in Breast Cancer Stem Cells.

ABSTRACT: Breast cancer is an aggressive disease with a high incidence in women worldwide. Two decades ago, a controversial hypothesis was proposed that cancer arises from a subpopulation of "tumor initiating cells" or "cancer stem cells-like" (CSC). Today, CSC are defined as small subset of somatic cancer cells within a tumor with self-renewal properties driven by the aberrant expression of genes involved in the maintenance of a stemness-like phenotype. The understanding of the underlying cellular and molecular mechanisms involved in the maintenance of CSC subpopulation are fundamental in the development and persistence of breast cancer. Nowadays, the hypothesis suggests that genetic and epigenetic alterations give rise to breast cancer stem cells (bCSC), which are responsible for self-renewal, tum

SUBMITTER: Flores-Huerta N 

PROVIDER: S-EPMC7998729 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature