The Association between HDL-C and Subclinical Atherosclerosis Depends on CETP Plasma Concentration: Insights from the IMPROVE Study.

ABSTRACT: The impact of cholesteryl ester transfer protein (CETP) on atherosclerosis is highly debated. This study aimed to investigate the associations between plasma CETP or CETP genotypes and carotid intima-media thickness (cIMT) and the influence of high-density lipoprotein cholesterol (HDL-C) on these associations. Plasma CETP and HDL-C concentrations were measured in 552 subjects free of any pharmacological treatment from the IMPROVE cohort, which includes 3711 European subjects at high cardiovascular risk. CETP single-nucleotide polymorphisms (SNPs) and cIMT measures (cIMT_max; cIMT_mean-max of bifurcations, common and internal carotids; plaque-free common carotid [PF CC]-IMT_mean) were available for the full cohort. In drug-free subjects, plasma CETP correlated

SUBMITTER: Colombo GI 

PROVIDER: S-EPMC7999018 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature