Image-Guided Brachytherapy for Salvage Reirradiation: A Systematic Review.

ABSTRACT:

Background

Local recurrence in gynecological malignancies occurring in a previously irradiated field is a challenging clinical issue. The most frequent curative-intent treatment is salvage surgery. Reirradiation, using three-dimensional image-guided brachytherapy (3D-IGBT), might be a suitable alternative. We reviewed recent literature concerning 3D-IGBT for reirradiation in the context of local recurrences from gynecological malignancies.

Methods

We conducted a large-scale literature research, and 15 original studies, responding to our research criteria, were finally selected.

Results

Local control rates ranged from 44% to 71.4% at 2-5 years, and overall survival rates ranged from 39.5% to 78% at 2-5 years. Grade ≥3 toxicities ranged from 1.7% to 50%, with only one s

SUBMITTER: Bockel S 

PROVIDER: S-EPMC7999189 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature