Urinary Exosomes Identify Inflammatory Pathways in Vancomycin Associated Acute Kidney Injury.

ABSTRACT: Vancomycin is commonly used as a first line therapy for gram positive organisms such as methicillin resistant Staphylococcusaureus. Vancomycin-induced acute kidney injury (V-AKI) has been reported in up to 43% of patients, especially in those with higher targeted trough concentrations. The precise mechanism of injury in humans remains elusive, with recent evidence directed towards proximal tubule cell apoptosis. In this study, we investigated the protein contents of urinary exosomes in patients with V-AKI to further elucidate biomarkers of mechanisms of injury and potential responses. Urine samples from patients with V-AKI who were enrolled in the DIRECT study and matched healthy controls from the UAB-UCSD O'Brien Center Biorepository were included in the analysis. Exosomes were extracted

SUBMITTER: Awdishu L 

PROVIDER: S-EPMC7999309 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature