Shifting the Gears of Metabolic Plasticity to Drive Cell State Transitions in Cancer.

ABSTRACT: Cancer metabolism is a hallmark of cancer. Metabolic plasticity defines the ability of cancer cells to reprogram a plethora of metabolic pathways to meet unique energetic needs during the various steps of disease progression. Cell state transitions are phenotypic adaptations which confer distinct advantages that help cancer cells overcome progression hurdles, that include tumor initiation, expansive growth, resistance to therapy, metastasis, colonization, and relapse. It is increasingly appreciated that cancer cells need to appropriately reprogram their cellular metabolism in a timely manner to support the changes associated with new phenotypic cell states. We discuss metabolic alterations that may be adopted by cancer cells in relation to the maintenance of cancer stemness, activation of

SUBMITTER: Wu Z 

PROVIDER: S-EPMC7999312 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature