Prognostic and Clinicopathological Significance of <i>CCND1</i>/Cyclin D1 Upregulation in Melanomas: A Systematic Review and Comprehensive Meta-Analysis.

ABSTRACT: Our objective was to evaluate the prognostic and clinicopathological significance of cyclin D1 (CD1) overexpression/CCND1 amplification in melanomas. We searched studies published before September 2019 (PubMed, Embase, Web of Science, Scopus). We evaluated the quality of the studies included (QUIPS tool). The impact of CD1 overexpression/CCND1 amplification on overall survival and relevant clinicopathological characteristic were meta-analyzed. We performed heterogeneity, sensitivity, small-study effects, and subgroup analyses. Forty-one studies and 3451 patients met inclusion criteria. Qualitative evaluation demonstrated that not all studies were performed with the same rigor, finding the greatest risk of bias in the study confounding domain. Quantitative evaluation showed that immunohisto

SUBMITTER: Gonzalez-Ruiz L 

PROVIDER: S-EPMC7999631 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature