The State of the Art and Prospects for Osteoimmunomodulatory Biomaterials.

ABSTRACT: The critical role of the immune system in host defense against foreign bodies and pathogens has been long recognized. With the introduction of a new field of research called osteoimmunology, the crosstalk between the immune and bone-forming cells has been studied more thoroughly, leading to the conclusion that the two systems are intimately connected through various cytokines, signaling molecules, transcription factors and receptors. The host immune reaction triggered by biomaterial implantation determines the in vivo fate of the implant, either in new bone formation or in fibrous tissue encapsulation. The traditional biomaterial design consisted in fabricating inert biomaterials capable of stimulating osteogenesis; however, inconsistencies between the in vitro and in vivo results were rep

SUBMITTER: Negrescu AM 

PROVIDER: S-EPMC7999637 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature