Drug Repurposing to Treat Glucocorticoid Resistance in Asthma.

ABSTRACT: Corticosteroid resistance causes significant morbidity in asthma, and drug repurposing may identify timely and cost-effective adjunctive treatments for corticosteroid resistance. In 95 subjects from the Childhood Asthma Management Program (CAMP) and 19 subjects from the Severe Asthma Research Program (SARP), corticosteroid response was measured by the change in percent predicted forced expiratory volume in one second (FEV₁). In each cohort, differential gene expression analysis was performed comparing poor (resistant) responders, defined as those with zero to negative change in FEV₁, to good responders, followed by Connectivity Map (CMap) analysis to identify inversely associated (i.e., negatively connected) drugs that reversed the gene expression profile of poor resp

SUBMITTER: Wang AL 

PROVIDER: S-EPMC7999884 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature