The Mutation Profile of SARS-CoV-2 Is Primarily Shaped by the Host Antiviral Defense.

ABSTRACT: Understanding SARS-CoV-2 evolution is a fundamental effort in coping with the COVID-19 pandemic. The virus genomes have been broadly evolving due to the high number of infected hosts world-wide. Mutagenesis and selection are two inter-dependent mechanisms of virus diversification. However, which mechanisms contribute to the mutation profiles of SARS-CoV-2 remain under-explored. Here, we delineate the contribution of mutagenesis and selection to the genome diversity of SARS-CoV-2 isolates. We generated a comprehensive phylogenetic tree with representative genomes. Instead of counting mutations relative to the reference genome, we identified each mutation event at the nodes of the phylogenetic tree. With this approach, we obtained the mutation events that are independent of each other and ge

SUBMITTER: Azgari C 

PROVIDER: S-EPMC7999997 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature