Post-Translational Modifications of Retroviral HIV-1 Gag Precursors: An Overview of Their Biological Role.

ABSTRACT: Protein post-translational modifications (PTMs) play key roles in eukaryotes since they finely regulate numerous mechanisms used to diversify the protein functions and to modulate their signaling networks. Besides, these chemical modifications also take part in the viral hijacking of the host, and also contribute to the cellular response to viral infections. All domains of the human immunodeficiency virus type 1 (HIV-1) Gag precursor of 55-kDa (Pr55Gag), which is the central actor for viral RNA specific recruitment and genome packaging, are post-translationally modified. In this review, we summarize the current knowledge about HIV-1 Pr55Gag PTMs such as myristoylation, phosphorylation, ubiquitination, sumoylation, methylation, and ISGylation in order to figure out how these modifications a

SUBMITTER: Bussienne C 

PROVIDER: S-EPMC8000049 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature