Peptide Dendrimers with Non-Symmetric Bola Structure Exert Long Term Effect on Glioblastoma and Neuroblastoma Cell Lines.

ABSTRACT:

Background

Glioblastoma (GBM) is the most common malignant tumor of the central nervous system (CNS). Neuroblastoma (NB) is one of the most common cancers of childhood derived from the neural crest cells. The survival rate for patients with GBM and high-risk NB is poor; therefore, novel therapeutic approaches are needed. Increasing evidence suggests a dual role of redox-active compounds in both tumorigenesis and cancer treatment. Therefore, in this study, polyfunctional peptide-based dendrimeric molecules of the bola structure carrying residues with antiproliferative potential on one side and the antioxidant residues on the other side were designed.

Methods

We synthesized non-symmetric bola dendrimers and assessed their radical scavenging potency as well as redox capability.

SUBMITTER: Sowinska M 

PROVIDER: S-EPMC8000084 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature