Evidence supporting a time-limited hippocampal role in retrieving autobiographical memories.

ABSTRACT: The necessity of the human hippocampus for remote autobiographical recall remains fiercely debated. The standard model of consolidation predicts a time-limited role for the hippocampus, but the competing multiple trace/trace transformation theories posit indefinite involvement. Lesion evidence remains inconclusive, and the inferences one can draw from functional MRI (fMRI) have been limited by reliance on covert (silent) recall, which obscures dynamic, moment-to-moment content of retrieved memories. Here, we capitalized on advances in fMRI denoising to employ overtly spoken recall. Forty participants retrieved recent and remote memories, describing each for approximately 2 min. Details associated with each memory were identified and modeled in the fMRI time-series data using a variant of t

SUBMITTER: Gilmore AW 

PROVIDER: S-EPMC8000197 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature