Association between uric acid lowering and renal function progression: a longitudinal study

ABSTRACT:

Background

This study aimed to explore the association between uric acid lowering and renal function.

Materials and Methods

We conducted a population-based cohort study with 1,534 subjects for 4 years from 2012 to 2016. The population was divided into four groups according to the interquartile range of changes in serum uric acid with quartile 1 representing lower quarter. Renal function decline was defined as eGFR decreased more than 10% from baseline in 2016. Renal function improvement was defined as eGFR increased more than 10% from baseline in 2016. Cox regression analysis was used to calculate the hazard ratio (HR) and 95% confidence interval (CI).

Results

In the adjusted Cox regression models, compared to quartile 4, quartile 1 (HR = 0.64, 95% CI [0.49–0.85]

SUBMITTER: Liu L 

PROVIDER: S-EPMC8000451 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature