Characteristics of the gut microbiome in patients with prediabetes and type 2 diabetes.

ABSTRACT:

Background

Gut microbiome has recently been identified as a new potential risk factor in addition to well-known diabetes risk factors. The aim of this study was to analyze the differences in the composition of gut microbiome in prediabetes(PreDM), type 2 diabetes mellitus (T2DM) and non-diabetic controls.

Methods

A total of 180 participants were recruited for this study: 60 with T2DM, 60 with PreDM and 60 non-diabetics (control group). Fecal samples were collected from the participants and genomic DNA was extracted. The composition and diversity of gut microbiome were investigated in fecal DNA samples using Illumina sequencing of the V3∼V4 regions of 16sRNA.

Results

There were significant differences in the number of bacteria among patients with PreDM and T2DM and the

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC8000457 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature