JNK signaling prevents biliary cyst formation through a CASPASE-8-dependent function of RIPK1 during aging.

ABSTRACT: The c-Jun N-terminal kinase (JNK) signaling pathway mediates adaptation to stress signals and has been associated with cell death, cell proliferation, and malignant transformation in the liver. However, up to now, its function was experimentally studied mainly in young mice. By generating mice with combined conditional ablation of Jnk1 and Jnk2 in liver parenchymal cells (LPCs) (JNK1/2^LPC-KO mice; KO, knockout), we unraveled a function of the JNK pathway in the regulation of liver homeostasis during aging. Aging JNK1/2^LPC-KO mice spontaneously developed large biliary cysts that originated from the biliary cell compartment. Mechanistically, we could show that cyst formation in livers of JNK1/2^LPC-KO mice was dependent on receptor-interacting pr

SUBMITTER: Muller K 

PROVIDER: S-EPMC8000530 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature