Improved Dermal and Transdermal Delivery of Curcumin with SmartFilms and Nanocrystals.

ABSTRACT: Poor aqueous solubility of active compounds is a major issue in today's drug delivery. In this study the smartFilm-technology was exploited to improve the dermal penetration efficacy of a poorly soluble active compound (curcumin). Results were compared to the dermal penetration efficacy of curcumin from curcumin bulk suspensions and nanocrystals, respectively. The smartFilms enabled an effective dermal and transdermal penetration of curcumin, whereas curcumin bulk- and nanosuspensions were less efficient when the curcumin content was similar to the curcumin content in the smartFilms. Interestingly, it was found that increasing numbers of curcumin particles within the suspensions increased the passive dermal penetration of curcumin. The effect is caused by an aqueous meniscus that is create

SUBMITTER: Eckert RW 

PROVIDER: S-EPMC8000619 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature