Hazardous Effects of SiO₂ Nanoparticles on Liver and Kidney Functions, Histopathology Characteristics, and Transcriptomic Responses in Nile Tilapia (Oreochromis niloticus) Juveniles.

ABSTRACT: The current investigation assessed the impacts of sub-lethal concentrations of silicon dioxide nanoparticles (SiO₂NPs) on hepato-renal functions, histopathological characteristics, and gene transcription in gills and liver of Nile tilapia juveniles. Fish were exposed to 20, 40, and 100 mg/L of SiO₂NPs for 3 weeks. Pairwise comparisons with the control group showed a significant dose-dependent elevation in serum ALP, ALT, and AST enzyme activities as well as blood urea and creatinine levels in SiO₂NP-intoxicated groups. Exposure to 100 mg/L SiO₂NPs significantly upregulated expression of HSP70, TNF-α, IL-1β, and IL-8 genes in the gills as compared to the control group. Moreover, exposure to 100 mg/L SiO₂NPs s

SUBMITTER: Abdel-Latif HMR 

PROVIDER: S-EPMC8000872 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature