Comparative Study of Gold and Carbon Nanoparticles in Nucleic Acid Lateral Flow Assay.

ABSTRACT: A lateral flow assay (LFA) is a paper-based, point-of-need test designed to detect a specific analyte in complex samples in low-resource settings. Although LFA has been successfully used in different applications, its use is still limited when high sensitivity is required, especially in the diagnosis of an early-stage condition. The limit of detection (LOD) is clearly related to the signal-generating system used to achieve the visual readout, in many cases involving nanoparticles coupled to a biomolecule, which, when combined, provides sensitivity and specificity, respectively. While colloidal gold is currently the most-used label, other detection systems are being developed. Carbon nanoparticles (CNPs) demonstrate outstanding features to improve the sensitivity of this technology by produ

SUBMITTER: Porras JC 

PROVIDER: S-EPMC8000918 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature