What Do We Know about the Long-Term Course of Early Onset Bipolar Disorder? A Review of the Current Evidence.

ABSTRACT:

Aim

Early onset of psychopathology is often an index of a more severe clinical course and worse prognosis. This review examined the course of bipolar disorder (BD) with onset in childhood and adolescence, with a focus on persistence of symptoms, severity of illness, comorbidity, and functional impairment.

Methods

The databases of PubMed, Embase, and PsycInfo were systematically searched for publications since 1990 reporting on long-term (12 months or longer) assessments of patients with early onset BD.

Results

Forty-two relevant publications were identified, which reported on data derived from 15 different patient cohorts, including 7 prospective research psychopathology studies, 4 medical record reviews, 2 follow-ups of clinical trial samples, 1 managed care database

SUBMITTER: Cirone C 

PROVIDER: S-EPMC8001096 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature