Assessing the Associations of Growth Differentiation Factor 15 with Rheumatic Diseases Using Genetic Data.

ABSTRACT:

Objective

To investigate the potential causal associations of circulating levels of growth differentiation factor 15 (GDF-15) with the risk of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) using a Mendelian randomization (MR) design.

Methods

A genome-wide association study (GWAS) of GDF-15 among 5,440 individuals of European ancestry was used to identify genetic instruments. Summary statistics of SLE, RA and IBD were obtained from publicly available GWASs. We conducted an MR study using the inverse-variance weighted (IVW) method, supplemented with simple-median and weighted-median methods. Cochran Q test and MR-Egger regression were used to detect potential heterogeneity and directional pleiotropy. Odds ratios (ORs) with 9

SUBMITTER: Ye D 

PROVIDER: S-EPMC8001121 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature