Interactions of HIV-1 Capsid with Host Factors and Their Implications for Developing Novel Therapeutics.

ABSTRACT: The Human Immunodeficiency Virus type 1 (HIV-1) virion contains a conical shell, termed capsid, encasing the viral RNA genome. After cellular entry of the virion, the capsid is released and ensures the protection and delivery of the HIV-1 genome to the host nucleus for integration. The capsid relies on many virus-host factor interactions which are regulated spatiotemporally throughout the course of infection. In this paper, we will review the current understanding of the highly dynamic HIV-1 capsid-host interplay during the early stages of viral replication, namely intracellular capsid trafficking after viral fusion, nuclear import, uncoating, and integration of the viral genome into host chromatin. Conventional anti-retroviral therapies primarily target HIV-1 enzymes. Insights of capsid s

SUBMITTER: Zhuang S 

PROVIDER: S-EPMC8001122 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature