Glycosaminoglycans: Carriers and Targets for Tailored Anti-Cancer Therapy.

ABSTRACT: The tumor microenvironment (TME) is composed of cancerous, non-cancerous, stromal, and immune cells that are surrounded by the components of the extracellular matrix (ECM). Glycosaminoglycans (GAGs), natural biomacromolecules, essential ECM, and cell membrane components are extensively altered in cancer tissues. During disease progression, the GAG fine structure changes in a manner associated with disease evolution. Thus, changes in the GAG sulfation pattern are immediately correlated to malignant transformation. Their molecular weight, distribution, composition, and fine modifications, including sulfation, exhibit distinct alterations during cancer development. GAGs and GAG-based molecules, due to their unique properties, are suggested as promising effectors for anticancer therapy. Consid

SUBMITTER: Berdiaki A 

PROVIDER: S-EPMC8001210 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature