Sex-Related Differences in Regional Blood-Brain Barrier Integrity in Non-Demented Elderly Subjects.

ABSTRACT: The role of the blood-brain barrier (BBB) breakdown has been recognized as being important in Alzheimer's disease pathogenesis. We aimed to evaluate whether regional BBB integrity differed according to sex and whether differences in BBB integrity changed as a consequence of aging or cognitive decline, using dynamic contrast-enhanced (DCE)-magnetic resonance imaging (MRI). In total, 75 participants with normal cognition (NC) or mild cognitive impairment (MCI) underwent cognitive assessments and MRI examination including DCE-MRI. Regional K_trans was calculated in cortical regions and the Patlak permeability model was used to calculate BBB permeability (K_trans, min^-1). Females had a lower median K_trans in the cingulate and occipital cortices. In the

SUBMITTER: Moon Y 

PROVIDER: S-EPMC8001339 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature