Aqueous Humor Proteomic Alterations Associated with Visual Field Index Parameters in Glaucoma Patients: A Pilot Study.

ABSTRACT:

Purpose

The purpose of this study was to discover the aqueous humor proteomic changes associated with visual field indices in glaucoma patients.

Methods

Aqueous humor samples were analyzed using Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS). The visual fields were analyzed with the Humphrey Visual Field analyzer. Statistical analyses were performed to discover the relationship between the aqueous humor proteins and visual field parameters including Pattern Standard Deviation (PSD), Visual Field Index (VFI), Mean Deviation (MD) and Glaucoma Hemifield Test (GHT).

Results

In total, 222 proteins were identified in 49 aqueous humor samples. A total of 11, 9, 7, and 6 proteins were significantly correlated with PSD, VFI, MD, and GHT respectively. These proteins

SUBMITTER: Kodeboyina SK 

PROVIDER: S-EPMC8001447 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature