Degradation Mechanism of Porous Metal-Organic Frameworks by In Situ Atomic Force Microscopy.

ABSTRACT: In recent years, Metal-Organic Frameworks (MOFs) have attracted a growing interest for biomedical applications. The design of MOFs should take into consideration the subtle balance between stability and biodegradability. However, only few studies have focused on the MOFs' stability in physiological media and their degradation mechanism. Here, we investigate the degradation of mesoporous iron (III) carboxylate MOFs, which are among the most employed MOFs for drug delivery, by a set of complementary methods. In situ AFM allowed monitoring with nanoscale resolution the morphological, dimensional, and mechanical properties of a series of MOFs in phosphate buffer saline and in real time. Depending on the synthetic route, the external surface presented either well-defined crystalline planes or i

SUBMITTER: Christodoulou I 

PROVIDER: S-EPMC8001454 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature