The Effect of Maternal Immune Activation on Social Play-Induced Ultrasonic Vocalization in Rats.

ABSTRACT: Prenatal maternal infection is associated with an increased risk of various neurodevelopmental disorders, including autism spectrum disorders (ASD). Maternal immune activation (MIA) can be experimentally induced by prenatal administration of polyinosinic:polycytidylic acid (poly I:C), a synthetic viral-like double-stranded RNA. Although this MIA model is adopted in many studies, social and communicative deficits, included in the first diagnostic criterion of ASD, are poorly described in the offspring of poly(I:C)-exposed dams. This study aimed to characterize the impact of prenatal poly(I:C) exposure on socio-communicative behaviors in adolescent rats. For this purpose, social play behavior was assessed in both males and females. We also analyzed quantitative and structural changes in ultr

SUBMITTER: Gzielo K 

PROVIDER: S-EPMC8001568 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature