Degenerative Cervical Myelopathy: Insights into Its Pathobiology and Molecular Mechanisms.

ABSTRACT: Degenerative cervical myelopathy (DCM), earlier referred to as cervical spondylotic myelopathy (CSM), is the most common and serious neurological disorder in the elderly population caused by chronic progressive compression or irritation of the spinal cord in the neck. The clinical features of DCM include localised neck pain and functional impairment of motor function in the arms, fingers and hands. If left untreated, this can lead to significant and permanent nerve damage including paralysis and death. Despite recent advancements in understanding the DCM pathology, prognosis remains poor and little is known about the molecular mechanisms underlying its pathogenesis. Moreover, there is scant evidence for the best treatment suitable for DCM patients. Decompressive surgery remains the most ef

SUBMITTER: Tu J 

PROVIDER: S-EPMC8001572 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature