Impact of Surface Properties of Core Material on the Stability of Hot Melt-Coated Multiparticulate Systems.

ABSTRACT: Hot melt coating (HMC) of an active pharmaceutical ingredient (API) powder with lipid-based excipients is an innovative method for manufacturing patient-convenient dosage forms. However, drug release instability is still its main industrial challenge. The correlation between the unstable pharmaceutical product performance with the solid-state alteration of lipids is currently well-investigated. The remaining problem is the inconsistent release alteration of different APIs coated with the same lipid after storage, such as faster release in some cases and slower release in others. The interaction between API surface and lipid-based coating and its alteration during storage were investigated in this work. The surface properties of five different APIs and the coating composition of tripalmitin

SUBMITTER: Schertel S 

PROVIDER: S-EPMC8001618 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature